Population
Pigs (n=18) instrumented with a fixed occluder on the proximal left anterior descending coronary artery (LAD)
Comparison
Chronic coronary occlusion for 3 months vs Normal remote myocardial regions within the same…
Design
Preclinical
Follow-up
3 months
Authors
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Replicates hibernating myocardium features in a porcine model; extends preclinical tools while leaving human translation open.
A porcine model of chronic LAD occlusion successfully replicates the physiological features of hibernating myocardium, demonstrating reduced resting perfusion and increased FDG uptake, particularly in the subendocardium.
Fallavollita et al. (1997) studied this question.