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May 7, 2026Chemical Communications0 citationsOpen Access

Temperature and Lipid Composition Differentially Regulate KRAS Assemblies on Membranes

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JKJi young KangKEKacie EvansALArthur Laganowsky

Key Points

  • This research aims to elucidate how temperature and lipid composition affect KRAS assemblies on membranes.
  • Utilized variable-temperature native mass spectrometry to study KRAS dimerization.
  • Employed NanoBiT assays to investigate lipid interactions.
  • Analyzed the impact of different lipid compositions on KRAS signaling.
  • Conducted experiments under varying temperature conditions.
  • Identified temperature as a key regulator of KRAS dimerization on membranes.
  • Demonstrated that lipid composition significantly influences KRAS assemblies.
  • Found that alterations in lipid types affect signaling pathways associated with KRAS.

Abstract

RAS GTPases oligomerize on membranes to regulate signaling, but factors governing this process remain unclear. Using variable-temperature native mass spectrometry and NanoBiT assays, we show KRAS dimerization is lipid- and...

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Cite This Study

Kang et al. (2026) studied this question.

synapsesocial.com/papers/69fbef68164b5133a91a33b7https://doi.org/10.1039/d6cc01853j
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