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May 7, 2026Biochemistry and Biophysics ReportsOpen Access

The role of nasal microbiota and type 2 innate lymphoid cells in the pathogenesis of allergic rhinitis

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Authors

CWChen WangYZYi-Ming ZhangMZM M Zhou

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Overview

Animals with allergic rhinitis showed tissue remodeling and microbial dysbiosis, suggesting IL-33 aggravates type 2 inflammation and autophagy dysfunction.

Key Points

  • This research investigates the connections between nasal microbiota, type 2 innate lymphoid cells, and allergic rhinitis.
  • Mice were divided into control, AR, AR + IL-33, and AR + antibiotic groups (n=5)
  • ELISA measured IL-4, IL-5, and IL-13 levels
  • Masson staining evaluated tissue remodeling
  • Flow cytometry detected ILC2s and memory ILC2s
  • 16S rRNA sequencing analyzed nasal microbiota diversity
  • Mice with allergic rhinitis exhibited more nasal symptoms and enhanced tissue remodeling
  • IL-33 increased serum type 2 cytokines and nasal ILC2s
  • Reduced Proteobacteria and increased Firmicutes were observed in the IL-33 group
  • Autophagy and mitophagy dysfunction were indicated by increased p62 and LC3II/LC3I ratio

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69fbef86164b5133a91a371ehttps://doi.org/10.1016/j.bbrep.2026.102602
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