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May 7, 2026Wellcome Open ResearchOpen Access

Case Report: Conducting Clinical Trials during an Outbreak: An Mpox case report

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Authors

IKIsabella KyohairweMHMackline HopeHMHerman Mwanja

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Overview

Case report shows challenges in clinical trials during Mpox outbreak in HIV patients, highlighting adaptive management and infection control measures.

Key Points

  • This case report aims to address the operational and ethical challenges of conducting clinical trials during an infectious disease outbreak.
  • Describes an Mpox case during a therapeutic drug monitoring trial in Uganda.
  • Involves an adult male participant living with HIV experiencing a vesiculopustular rash.
  • Details infection prevention measures, trial procedures halting, and coordination with health authorities.
  • No secondary cases among study participants or personnel after 21 days of self-monitoring.
  • Continuity of HIV care maintained through remote adherence counselling and antiretroviral refill coordination.

Cite This Study

Kyohairwe et al. (2026) studied this question.

synapsesocial.com/papers/69fbefa3164b5133a91a3868https://doi.org/10.12688/wellcomeopenres.24722.1
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