⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

May 5, 2026Russian Journal of General Chemistry

Synthesis and Phosphonylation of 2-Hydrazinyl-5,6-disubstituted Pyrimidin-4(3H)-ones

Anastasia S. Skrylkova Dmitry M. Egorov A. S. Krylov Ekaterina Chernova

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to synthesize and phosphonylate 2-hydrazinyl-5,6-disubstituted pyrimidin-4(3H)-ones.
Synthesis of 2-hydrazinylpyrimidin-4-ones via reaction with hydrazine hydrate and S-methyl-2-thiouracil derivatives.
Phosphonylation of the synthesized compounds using chloroethynylphosphonates.
A series of new phosphonylated dihydroformazans were created.
The compounds contain pyrimidin-2-yl-4-one fragments.

Implication

Synthesis reveals new phosphonylated dihydroformazans from hydrazinyl derivatives and S-methyl-2-thiouracil, indicating potential applications in medicinal chemistry.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Skrylkova et al. (2026) studied this question.

synapsesocial.com/papers/69fbefc0164b5133a91a3c01 https://doi.org/10.1134/s1070363225607227

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Synthesis, spectroscopic characterization, and in vitro antimicrobial activity of fused pyrazolo[4′,3′:4,5]thieno[3,2‐d]pyrimidineOriginal Research · 2020 · 14 citations
2Synthesis of New 2-(5-Aryl-3-styryl-4,5-dihydro-1H-pyrazol-1-yl)-4-(trifluoromethyl)pyrimidinesOriginal Research · 2006 · 16 citations
3Synthesis of a New 2,4,6(1Н,3Н,5Н)Pyrimidinetrione Derivatives2025
44-[3-Dimethylamino-1-(2-dimethylaminovinyl]prop-2-enylidene]-2-phenyl-1,3-oxazol-5(4H)-one and 5-[3-Dimethylamino-1-(2-dimethylaminovinyl)prop-2-enylidene]-3-methyl-2-thioxo-1,3-thiazolidin-4-one in the Synthesis of 1,4-Dihydropyridine DerivativesOriginal Research · 2002 · 7 citations
5Antioxidant and Antimicrobial Activities of Some New Synthesized Triazole, Thiazolone, and Thiazine Containing Fused Rings of Imidazopyridine2024