Synthesis and Phosphonylation of 2-Hydrazinyl-5,6-disubstituted Pyrimidin-4(3H)-ones

Key Points

• The aim is to synthesize and phosphonylate 2-hydrazinyl-5,6-disubstituted pyrimidin-4(3H)-ones.
• Synthesis of 2-hydrazinylpyrimidin-4-ones via reaction with hydrazine hydrate and S-methyl-2-thiouracil derivatives.
• Phosphonylation of the synthesized compounds using chloroethynylphosphonates.
• A series of new phosphonylated dihydroformazans were created.
• The compounds contain pyrimidin-2-yl-4-one fragments.