What question did this study set out to answer?

To evaluate the synthesis and catalytic activity of new triazole‐substituted aryl iodides.

May 7, 2026

New Triazole‐Tethered Iodoarenes: Click‐Mediated Synthesis and Catalytic Activity Toward Oxidative Transformations

BBhartiJ.C. Bose University of Science & Technology, YMCA RRimiJ.C. Bose University of Science & Technology, YMCA TDToshifumi DohiRitsumeikan University

Key Points

To evaluate the synthesis and catalytic activity of new triazole‐substituted aryl iodides.
Synthesis of aryl iodides via Cu(I)‐mediated [3+2] cycloaddition with aryl azides.
Characterization of compounds using FT‐IR, 1 H NMR, 1 3 C NMR, and HRMS.
Assessment of catalytic potential in oxidative transformations.
Iodoarene 1c showed notable catalytic activity in the α‐oxytosylation of acetophenones.
Oxidation of sulfides was successfully demonstrated with synthesized compounds.
α‐Oxytosylated products were produced in excellent yields ranging from 67% to 94%.

Abstract

ABSTRACT A series of new triazole‐substituted aryl iodides 1a–d were synthesized by Cu(I)‐mediated 3+2 cycloaddition between 2‐iodo‐1,3‐bis(prop‐2‐yn‐1‐yloxy)benzene ( 4 ) and aryl azides 5a‐d . The structures of the synthesized compounds were confirmed by FT‐IR, 1 H NMR, 1 3 C NMR, and HRMS analyses. The catalytic potential of iodoarenes 1a–d was evaluated toward the oxidation of sulfides. Furthermore, iodoarene 1c exhibited remarkable catalytic activity in the α‐oxytosylation of acetophenones, affording the corresponding α‐oxytosylated products in excellent yields (67%–94%).

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