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Perspective article reveals Synaptic Pruning impacts neural substrate in seniors, suggesting Kinematic Resistance may sustain cognitive function.
The Century of Mitigation: Halting a Century of Synaptic Pruning in the Senior Substrate This perspective article examines the biological phenomenon of Synaptic Pruning—the systematic degradation of ocular-motor pathways due to visual and mechanical stagnation in the senior population. Traditionally, the aging process has been viewed through the lens of inevitable decline; however, this R&D trajectory posits that by shifting from passive visual consumption to Kinematic Resistance, the integrity of the neural substrate can be maintained. The Neuro-Art Enrichment (NAE™) protocol serves as the translational bridge, utilizing high-velocity visual tracking and precision motor tasks to "irrigate" neural architecture. Through the reverse-engineering of a primary recovery case, this paper documents functional gains in executive task completion, and linguistic articulation, providing a scalable, non-pharmacological framework for long-term cognitive maintenance.
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Valerie Del Valle (2026) studied this question.
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