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September 19, 2010Journal of Biological ChemistryOpen Access

Chylomicron- and VLDL-derived Lipids Enter the Heart through Different Pathways

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Population

Heart-specific lipoprotein lipase knock-out, CD36 knock-out (Cd36), and double knock-out (hLpL0/Cd36-DKO)…

Comparison

Genetic deletion of lipoprotein lipase, CD36, or… vs Control mice

Design

Preclinical

Authors

KBKalyani G. BharadwajUniversity of KentuckyYHYaeko HiyamaSunnybrook Health Science CentreYHYunying HuNew York University

Discussion

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Implication

Identifies distinct cardiac fatty acid uptake pathways in mice; leaves open translation to human metabolic heart disease.

Structured PICO

P
Population
Heart-specific lipoprotein lipase (LpL) knock-out (hLpL0), CD36 knock-out (Cd36(-/-)), and double knock-out (hLpL0/Cd36(-/-)-DKO) mice, along with tamoxifen-treated β-actin-MerCreMer/LpL(flox/flox) mice and ApoE knock-out mice.
I
Intervention
Genetic deletion of lipoprotein lipase (LpL), CD36, or both (double knock-out)
C
Comparator
Control mice
O
Outcome
Cardiac lipids (total fatty acyl-CoA), lipoprotein lipid uptake (VLDL-triglyceride, VLDL-cholesteryl ester, chylomicron TG, retinyl ester), and gene expressionsurrogate

This preclinical study identifies two distinct pathways for cardiac fatty acid uptake: a CD36-dependent process for VLDL-derived fatty acids and a non-CD36 process for chylomicron-derived fatty acids.

Cite This Study

Bharadwaj et al. (2010) studied this question.

synapsesocial.com/papers/69fc039f6d730ca589dd6f0ahttps://doi.org/10.1074/jbc.m110.174458
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of fatty acid transport by fatty acid translocase/CD362004 · 199 citations
  2. 2Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: Direct evidence that lipoprotein lipase bridging occurs <i>in vivo</i>1998 · 153 citations
  3. 3Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion1989 · 488 citations
  4. 4Detection and characterization of the heterozygote state for lipoprotein lipase deficiency.1989 · 293 citations
  5. 5Rescue of Cardiomyopathy in Peroxisome Proliferator-Activated Receptor-α Transgenic Mice by Deletion of Lipoprotein Lipase Identifies Sources of Cardiac Lipids and Peroxisome Proliferator-Activated Receptor-α Activators2010 · 120 citations