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May 4, 2026Inorganic Chemistry

Hydrodefluorination of a Fluorobenzene Equivalent by Harnessing a P(III)/Pd(II)–P(V)/Pd(0) Redox Couple Using a P–CF ₃ -Functionalized Benzazaphosphole

Preston M. Miura-Akagi Yuri J.H. Ah-Tye Jonah G. Clark Kevin P. Quirion Wang‐Yeuk Kong Miranda P. Howard Landon Balkwill Wesley Y. Yoshida Glenn P. A. Yap Arnold L. Rheingold Daniel H. Ess Russell P. Hughes Matthew F. Cain

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Key Points

The research aims to explore a method for removing fluorine from a fluorobenzene equivalent using a specific redox couple.
Utilized DFT calculations to evaluate redox reactions
Analyzed the efficiency of a P(III)/Pd(II)–P(V)/Pd(0) system
Investigated the impact of P–CF₃ functionalization on the reaction
Demonstrated successful hydrodefluorination of the fluorobenzene equivalent
Achieved improved reaction efficiency with the functionalized benzazaphosphole
DFT calculations indicated favorable redox properties

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Implication

Evaluates redox reactions in a fluorobenzene equivalent, indicating a new approach to fluorine removal.

Abstract

redox reaction were evaluated by DFT calculations.

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Cite This Study

Miura-Akagi et al. (2026) studied this question.

synapsesocial.com/papers/69fc2b158b49bacb8b347652 https://doi.org/10.1021/acs.inorgchem.6c00734

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