Narrative review reveals the genetic pathogenesis and management in tuberous sclerosis complex, highlighting multidisciplinary therapeutic strategies.
The tuberous sclerosis complex (TSC), a multisystem, autosomal dominant disorder affecting children and adults, results from mutations in one of two genes, TSC1 (encoding hamartin) or TSC2 (encoding tuberin). In this article, the current knowledge of the pathogenesis of the disease and its management are discussed.
No takes yet. Share an insight, caveat, or question.
Crino et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: