3+3 Annulation of Vinyl Sulfoxonium Ylides and Difluoroacetohydrazonoyl Bromides for Synthesis of 3-Difluoromethyl 1,6-Dihydropyridazine Derivatives

Key Points

• To develop an efficient method for synthesizing 3-difluoromethyl 1,6-dihydropyridazine derivatives through annulation.
• Utilized a [3+3] annulation reaction
• Reacted vinyl sulfonium ylides with difluoroacetohydrazonoyl bromides
• Conducted the reaction in the presence of sodium carbonate as a base.
• Successfully synthesized 3-difluoromethyl 1,6-dihydropyridazine derivatives
• Achieved high yields in the annulation reaction
• Demonstrated the viability of vinyl sulfoxonium ylides as key intermediates.