Demonstrates reprogramming of carbon and amino acid metabolism in Acinetobacter baumannii, indicating a new pathway for enhancing antibacterial effects.
. Combination therapy drives a shift from central carbon metabolism toward amino acid and ion metabolism. Enzymes such as isocitrate lyase, malate synthase, and aspartate deaminase-absent in mammals-represent potential targets to enhance synergistic antibacterial effects.
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Bian et al. (2026) studied this question.
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