Air Pollution and Incidence of Dementia

BACKGROUND AND OBJECTIVES: Studies of association between air pollution and incidence of dementia have shown discrepant results. The aim of this study was to evaluate the association between air pollution and dementia. METHODS: ) in those aged >40 years were included. Data were extracted by 2 independent investigators. The main outcome was the pooled HR for dementia per increment of pollutant, calculated using a random-effects model. Results were reported in accordance with PRISMA guidelines. The protocol was registered in PROSPERO (registration number: CRD42020219036). RESULTS: = 82%) was less clear, although a significant association could not be ruled out, and there was high heterogeneity across studies. DISCUSSION: exposure. However, results should be interpreted in light of the small number of studies and high heterogeneity of effects across studies.