Why the study?
Does adoptive transfer of IL-4 expressing T cells reduce the severity of EAE in myelin basic protein-immunized mice?
Population
Myelin basic protein-immunized mice (model for Experimental autoimmune encephalomyelitis)
Design
Preclinical
Authors
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Supports site-specific cytokine delivery by engineered T cells in EAE models; leaves open translation to human autoimmune disease.
Does adoptive transfer of IL-4 expressing T cells reduce the severity of EAE in myelin basic protein-immunized mice?
T lymphocytes transduced with retroviral vectors can deliver regulatory cytokines site-specifically, representing a potential therapeutic strategy for autoimmune diseases.
Shaw et al. (1997) studied this question.
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