Fundamental Relationships between Structure, Reactivity, and Biological Activity for the Duocarmycins and CC-1065

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTFundamental Relationships between Structure, Reactivity, and Biological Activity for the Duocarmycins and CC-1065Karen S. MacMillan and Dale L. Boger*View Author Information Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037*To whom correspondence should be addressed. Phone: (858) 784-7522. Fax: (858) 784-7550. E-mail: [email protected]Cite this: J. Med. Chem. 2009, 52, 19, 5771–5780Publication Date (Web):July 29, 2009Publication History Received11 May 2009Published online29 July 2009Published inissue 8 October 2009https://doi.org/10.1021/jm9006214Copyright © 2009 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2485Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (2 MB) Get e-AlertsSUBJECTS:Alcohols,Amides,Genetics,Post-translational modification,Reactivity Get e-Alerts