Does sacubitril/valsartan reduce clinic and ambulatory central aortic and brachial pressures in elderly patients with systolic hypertension and stiff arteries compared to olmesartan?
Sacubitril/valsartan is superior to olmesartan in reducing central aortic and brachial pressures in elderly patients with systolic hypertension and stiff arteries.
<0.002). Both treatments were equally well tolerated. The PARAMETER study (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin Receptor Blocker Measuring Arterial Stiffness in the Elderly), for the first time, demonstrated superiority of sacubitril/valsartan versus olmesartan in reducing clinic and ambulatory central aortic and brachial pressures in elderly patients with systolic hypertension and stiff arteries.
Williams et al. (2017) studied this question.