Update on atopic dermatitis

Shannon Meledathu; Malini P. Naidu; Patrick M. Brunner

doi:10.1016/j.jaci.2025.01.013

January 22, 2025Journal of Allergy and Clinical ImmunologyOpen Access

Update on atopic dermatitis

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Key Points

To summarize recent developments in the characterization, pathogenesis, diagnosis, and targeted therapeutic management of atopic dermatitis.
Narrative review synthesizing recent clinical and translational literature on atopic dermatitis.
Evaluated emerging data on molecular endotypes, clinical phenotypes, the skin microbiome, and novel diagnostic tools.
Summarized molecular mechanisms driving disease pathogenesis and assessed targeted therapeutic interventions.
Characterized distinct molecular endotypes and diverse clinical phenotypes, detailing how microbial dysbiosis in the skin microbiome contributes to chronic inflammation.
Identified substantial advancements in diagnostic precision and the clinical deployment of targeted therapies that have transformed treatment standards for affected patients.

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Implication

Narrative review uncovers advances in molecular endotypes and targeted therapies in atopic dermatitis, highlighting a transformation in precision diagnostic and therapeutic strategies.

Abstract

Atopic dermatitis is the most common chronic inflammatory skin condition. This review highlights most recent advances in understanding and treating this debilitating disease. We summarize new insights regarding molecular endotypes and clinical phenotypes that characterize atopic dermatitis, the role of the skin microbiome, and improvements in diagnostic tools. We also emphasize recent scientific advancements in understanding the mechanisms driving atopic dermatitis pathogenesis and discuss the identification and implementation of new targeted treatment approaches that have revolutionized therapeutic options for affected patients.

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Meledathu et al. (2025) studied this question.

synapsesocial.com/papers/69fd1e6f015782f43c509a8b https://doi.org/10.1016/j.jaci.2025.01.013

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Update on atopic dermatitis

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Update on atopic dermatitis

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