June 1, 1999AJP Heart and Circulatory Physiology

Angiotensin II and mechanical stretch induce production of tumor necrosis factor in cardiac fibroblasts

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

neonatal rat cardiac myocytes and fibroblasts

Intervention

ANG II (>/=10(-8) M), lipopolysaccharide (LPS), or cyclic mechanical stretch for 6 h

Outcome

production of tumor necrosis factor (TNF) and expression of TNF-alpha mRNAsurrogate

Activation of the renin-angiotensin system and mechanical stress stimulate TNF production in cardiac fibroblasts, which can be inhibited by beta-adrenergic receptor activation.

Authors

TYTomoyuki YokoyamaGunma University KSKenichi SekiguchiUtsunomiya University TTToru TanakaToho University

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support clinical TNF targeting yet; leaves open fibroblast-specific mechanisms in ANG II- and stretch-mediated remodeling.

Cite This Study

Yokoyama et al. (1999) studied this question.

synapsesocial.com/papers/69fd27bb180198535449026c https://doi.org/10.1152/ajpheart.1999.276.6.h1968

View Full Paper

Ask AI

Bookmark

Angiotensin II and mechanical stretch induce production of tumor necrosis factor in cardiac fibroblasts

Structured PICO

Discussion

Implication

Cite This Study

Angiotensin II and mechanical stretch induce production of tumor necrosis factor in cardiac fibroblasts

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider