Noninvasive Prediction of Elevated Wedge Pressure in Pulmonary Hypertension Patients Without Clear Signs of Left‐Sided Heart Disease: External Validation of the OPTICS Risk Score

Figure 1. Receiver operator characteristic (ROC) curve and optimal cutoff point of the OPTICS risk scoring system for prediction of postcapillary pulmonary hypertension. AUC indicates area under the curve.

Figure 2. Flowchart representing patients’ numbers and study methods of the external OPTICS cohort. CTEPH indicates chronic thromboembolic pulmonary hypertension; IPAH, idiopathic pulmonary arterial hypertension; LVEDP, left ventricular end‐diastolic pressure; PAH, pulmonary arterial hypertension; PAH‐CHD, pulmonary arterial hypertension due to congenital heart disease; PAH‐CTD, pulmonary arterial hypertension due to connective tissue disease; PCWP, pulmonary capillary wedge pressure; PH, pulmonary hypertension; PVOD, pulmonary veno occlusive disease; and RHC, right heart catheterization.

Figure 3. External validation of the OPTICS risk score and H2FPEF score. AUC indicates area under the curve.

Figure 4. Description of the OPTICS risk score and point allocation for each clinical parameter, with associated probability of having postcapillary PH, based on the total score as estimated from the model. HDL‐C indicates high‐density lipoprotein cholesterol; LDL‐C, low‐density lipoprotein cholesterol; PH, pulmonary hypertension; RV6, deflection in V6 in millimeters; and SV1, deflection in V1 in millimeters.

Figure 5. Pyramid graphs from the validation cohort of patients with postcapillary PH and precapillary PH, divided according to the OPTICS risk score outcomes or H2FPEF score outcomes of individual patients. The blue line represents a cutoff of ≥104 for the OPTICS risk score and ≥6 for the H2FPEF score. PH indicates pulmonary hypertension.

Figure 6. Probability analysis of postcapillary PH by H2FPEF score and OPTICS score, divided according to PH group. PH indicates pulmonary hypertension.