Why the study?
Does intracoronary infusion of tetrahydrobiopterin improve coronary artery endothelial function in patients with hypercholesterolaemia?
Population
18 patients with angiographically normal coronary arteries, of whom 9 had hypercholesterolaemia and 9 had…
Comparison
Intracoronary infusion of tetrahydrobiopterin 1… vs Acetylcholine infusion alone and…
Design
Cross-sectional
Authors
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BH4 may improve coronary endothelial function in hypercholesterolaemia; hypothesis-generating and should not yet change practice.
Does intracoronary infusion of tetrahydrobiopterin improve coronary artery endothelial function in patients with hypercholesterolaemia?
Intracoronary infusion of tetrahydrobiopterin restores coronary endothelial function in hypercholesterolaemic patients by improving nitric oxide bioavailability.
Yukihiro Fukuda (2002) studied this question.
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