Key result
Adding transcutaneous ultrasound to streptokinase increases arterial patency ~10-fold versus streptokinase alone.
Why the study?
External ultrasound has a synergistic effect on thrombus disruption with thrombolytic agents in vitro, but its effect on thrombolysis in vivo was unclear.
Does transcutaneous ultrasound augment thrombolysis with streptokinase in an in vivo rabbit model of arterial thrombosis?
RCT (n=24)
randomized
Does transcutaneous ultrasound augment thrombolysis with streptokinase in an in vivo rabbit model of arterial thrombosis?
Absolute Event Rate: 59% vs 6%
p-value: p=0.0012
Transcutaneous ultrasound significantly augments the thrombolytic effect of streptokinase in vivo, suggesting a potential non-invasive adjunct to pharmacological thrombolysis.
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May enhance thrombolysis when combined with streptokinase; leaves open translation to human arterial thrombosis.
Luo et al. (1996) conducted an RCT in Arterial thrombosis (n=24). Transcutaneous ultrasound + streptokinase vs. Streptokinase alone or ultrasound alone was evaluated on Angiographic patency (TIMI grade 3 flow) (p=0.0012). Transcutaneous ultrasound combined with intravenous streptokinase significantly increased angiographic patency of thrombosed arteries compared to streptokinase alone (59% vs 6%, P=0.0012).
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