Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study
Why the study?
Does a greater degree of adiposity and longer duration of obesity affect cardiac structure and function in young adults followed into midlife?
Population
2,547 participants of the CARDIA study who were 18-30 years old at baseline, were not obese at baseline, and…
Comparison
Greater degree of adiposity and longer duration… vs Lower degree of adiposity and shorter duration…
Design
Cohort
Follow-up
25 years
Authors
Discussion
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Member takes
Implication
Greater adiposity may promote concentric LV remodeling by midlife; leaves open causal effects and intervention benefits.
Structured PICO
Does a greater degree of adiposity and longer duration of obesity affect cardiac structure and function in young adults followed into midlife?
P
Population
2,547 participants of the CARDIA study who were 18-30 years old at baseline (1985-86), were not obese at baseline, and underwent an echocardiogram at the year 25 examination.
I
Intervention
Greater degree of adiposity (overall and abdominal) and longer duration of obesity
C
Comparator
Lower degree of adiposity and shorter duration of obesity
O
Outcome
Measures of cardiac structure and function (left ventricular mass, LV volume, LV mass-to-volume ratio, left atrial dimension, and ejection fraction) at year 25surrogate
A greater degree of adiposity is strongly associated with concentric LV remodeling in midlife, while a longer duration of obesity contributes to increased LV mass.
Cite This Study
Reis et al. (2014) studied this question.