May 1, 1963Journal of Applied Physiology

Relation between pressure and diameter in main pulmonary artery of man

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Population

11 patients undergoing open-heart surgery

Design

Cross-sectional

Authors

JGJoseph C. GreenfieldAmerican Mosquito Control Association DGD. M. GriggsUniversity of Missouri

Discussion

Member takes

Implication

Suggests reduced pulmonary artery elasticity in PH; hypothesis-generating for noninvasive assessment or targeted interventions.

Structured PICO

Population

11 patients undergoing open-heart surgery (8 with normal pulmonary artery pressure, 3 with pulmonary hypertension)

Intervention

Direct intraoperative measurement of main pulmonary artery diameter (via recording caliper sutured to the vessel wall) and lateral intravascular pressure (via 20-gauge needle and strain gauge)

Outcome

Pressure-diameter relationship in the main pulmonary artery (including ratio of change in radius to change in pressure [ΔR/ΔP], pressure-strain elastic modulus [Ep], and change in cross-sectional area)surrogate

Direct intraoperative measurements demonstrate the baseline pressure-strain elastic modulus of the human main pulmonary artery and indicate decreased elasticity in the setting of pulmonary hypertension.

Cite This Study

Greenfield et al. (1963) studied this question.

synapsesocial.com/papers/69fd2ce6f8347cff7f5d0bf5 https://doi.org/10.1152/jappl.1963.18.3.557

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