Interaction of Propionylated and Butyrylated Histone H3 Lysine Marks with Brd4 Bromodomains

Recognized as sisters: Histone modifications determine the state of chromatin remodeling and gene activation. Lysine propionylation and butyrylation have been identified as new histone marks (besides acetylation) that expand the epigenetic code. The alignment of the additional methylene groups of such propionylated (see picture) and butyrylated lysine residues between a highly conserved Pro–Phe motif suggests a general mode of bromodomain recognition. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.