The Human Histone Acetyltransferase P/CAF is a Promiscuous Histone Propionyltransferase

Catalytic promiscuity: The human histone acetyltransferase P/CAF can confer propionyl instead of acetyl marks onto peptides that mimic the H3 histone tail. Catalysis of propionyl transfer occurs with a kcat of 8.8 min−1 (versus a kcat of 12 min−1 observed for the transfer of an acetyl group) and with identical specificity for individual lysine residues in the H3 sequence. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2008/z700556_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.