Does renin-independent aldosteronism increase cardiovascular disease risk compared to renin-dependent aldosteronism or normal aldosterone in patients with hypertension?
Among hypertensive patients, renin-independent aldosteronism is associated with a significantly higher risk of cardiovascular disease compared to normal aldosterone or renin-dependent aldosteronism.
(identified as renin-dependent aldosteronism) showed an unchanged CVD risk. In CONPASS, renin-independent aldosteronism carried a significantly higher risk of CVD than normal aldosterone (odds ratio, 2.57 95% CI, 1.13-5.86), while the CVD risk remained unchanged in renin-dependent aldosteronism. Elevation of the urinary potassium-to-sodium excretion ratio, reflective of mineralocorticoid receptor activity, was only observed in participants with renin-independent aldosteronism. Conclusions Among patients with hypertension, renin-independent aldosteronism is more closely associated with CVD risk than renin-dependent aldosteronism.
Hu et al. (Fri,) studied this question.