Key result
Systemic tPA safely resolves massive PE in a patient with a profound hemoglobin of 4.5 g/dL.
Case Report (n=1)
No
Thrombolysis can be safely administered for life-threatening massive pulmonary embolism even in the presence of profound anaemia secondary to autoimmune haemolytic anaemia, provided there is no active bleeding.
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Lau et al. (2026) conducted a case report in Massive pulmonary embolism and profound anaemia (autoimmune haemolytic anaemia) (n=1). Recombinant tPA (rtPA) was evaluated on Clinical recovery and resolution of pulmonary emboli. Systemic thrombolysis with 100 mg recombinant tPA was successfully and safely administered to a patient with massive pulmonary embolism and profound anaemia (haemoglobin 4.5 g/dL).
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