May 8, 2007British Journal of PharmacologyOpen Access

Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+‐activated K+channels

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Population

Recombinant hSK1-3 and hIK channels expressed in HEK293 cells, and SK3 and IK channels endogenously…

Design

Preclinical

Authors

CHCharlotte HougaardUniversity of Copenhagen BEBirgitte L. EriksenNeuroSearch (Denmark)SJSine W. JørgensenSlagelse Hospital

Discussion

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Implication

CyPPA offers a selective SK2/SK3 probe for preclinical research; leaves open human translation and clinical utility.

Structured PICO

Population

Recombinant hSK1-3 and hIK channels expressed in HEK293 cells, and SK3 and IK channels endogenously expressed in TE671 and HeLa cells

Intervention

cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine (CyPPA)

Outcome

Modulation of channel activity (EC50 and efficacy)surrogate

CyPPA is identified as a subtype-selective positive modulator of SK2 and SK3 channels, providing a pharmacological tool to distinguish them from SK1 and IK channels.

Cite This Study

Hougaard et al. (2007) studied this question.

synapsesocial.com/papers/69fd7e03eaf018ad124b9fed https://doi.org/10.1038/sj.bjp.0707281

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Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+‐activated K+channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+‐activated K+channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider