Single-Nucleotide Polymorphisms Detection Base on Active-Matrix Digital Microfluidics Pyrosequencing Lab-on-a-chip Platform

Huiting Hu; Tong Wang; Bingbing Zhang; Kai Jin; Zihan Wang; Qi Huang; Hanbin Ma; Jinhua Li; Zhiyao Chen; Siyi Hu

doi:10.1039/d6sd00032k

January 1, 2025Sensors & DiagnosticsOpen Access

Single-Nucleotide Polymorphisms Detection Base on Active-Matrix Digital Microfluidics Pyrosequencing Lab-on-a-chip Platform

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Key Points

The project aims to develop a lab-on-a-chip platform for efficient detection of single-nucleotide polymorphisms (SNPs).
Utilized active-matrix digital microfluidics for SNP detection
Employed pyrosequencing technology
Integrated platform for streamlined genetic analysis
Achieved high accuracy in SNP detection
Demonstrated efficiency in processing samples via microfluidics
Improved detection speed compared to traditional methods

Implication

Shows effective SNP detection using digital microfluidics, indicating improved genetic analysis methods.

Abstract

Single-nucleotide polymorphisms (SNPs), as the most prevalent form of single-base variations within the genome, play a critical role in modulating protein function, regulating gene expression, and determing individual disease susceptibility,...

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Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/69fd7e5cbfa21ec5bbf069f5 https://doi.org/10.1039/d6sd00032k

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Single-Nucleotide Polymorphisms Detection Base on Active-Matrix Digital Microfluidics Pyrosequencing Lab-on-a-chip Platform

Key Points

Implication

Abstract

Discussion

Cite This Study

Single-Nucleotide Polymorphisms Detection Base on Active-Matrix Digital Microfluidics Pyrosequencing Lab-on-a-chip Platform

Key Points

Implication

Abstract

Discussion

Cite This Study

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