Exosome-modified mesoporous polydopamine with saikosaponin D and ferric ion for immunotherapy of metastatic breast cancer

Key Points

• This research aims to develop a targeted nanomedicine using exosomes for the treatment of metastatic breast cancer.
• Developed an exosome-modified mesoporous polydopamine nanomedicine (MFSE) loaded with saikosaponin D and ferric ion.
• Conducted in vitro and in vivo experiments to evaluate the efficacy of the treatment.
• Focused on the synergistic effects of photothermal therapy and immunotherapy.
• The MFSE showed enhanced tumor targeting and improved therapeutic efficacy compared to standard treatments.
• Significant reduction in tumor volume was observed with p<0.01 compared to controls.
• Increased immune cell activation was noted in treated models, indicating a promising immunotherapeutic effect.

Abstract