@LA mitigates the hypoxia-induced restriction on PDT, while the PTT-PDT synergy achieves potent antitumor efficacy under mild hyperthermia, enhancing treatment safety. In vitro experiments demonstrated the probe's excellent dissolved oxygen (DO) sensing performance, featuring a high resolution of 0.12 mg/L, a rapid response time of 1 s, and efficient ROS generation. Subsequently, the probe demonstrated dual functionality in vivo within a murine model, allowing pointwise identification of intratumoral hypoxic heterogeneity through DO sensing, while achieving complete inhibition of tumor growth. This study provides a new paradigm for the functional integration and efficacy enhancement of fiber-optic theranostics for in situ oncology, holding significant potential to advance the clinical translation of fiber-mediated phototherapies.
Z et al. (2026) studied this question.