Retroperitoneal Schwannoma with a Novel PRCC::TFE3 Fusion: Expanding the Spectrum of Schwannomas with a TFE3 Gene Rearrangement

Key Points

• To describe a rare subtype of retroperitoneal schwannoma associated with a novel TFE3 gene rearrangement.
• Case report detailing clinical presentation and molecular characterization of the schwannoma.
• Analysis of the PRCC::TFE3 fusion relationship with schwannoma pathology.
• Identification of a novel TFE3 gene rearrangement in the schwannoma.
• Enhanced understanding of schwannomas to prevent misdiagnosis with aggressive neoplasms.

Abstract