May 8, 2026Organic & Biomolecular Chemistry0 citations
Practical and Scalable Entry to Halogenated 1,4-Thiazines Through a Domino Morin-Rearrangement/Halogenation of N,S-Acetals and their Arylation Based on Suzuki-Miyaura Coupling
To develop a practical and scalable method for synthesizing halogenated thiazines.
Utilized Morin-rearrangement of N,S-acetals.
Conducted halogenation to introduce halides at the α-position of thiazines.
Employed Suzuki-Miyaura coupling for arylation.
Successfully synthesized thiazines with halides at α-position.
Demonstrated one or two-step synthesis efficiency without extensive conditions.
Provided a new scalable route that could enhance future applications in organic synthesis.
Abstract
Thiazines frameworks bearing a halide X (X = I, Br or Cl) at α-position of their sulfur atom were prepared in one or twosteps. The approach consists on Morin-rearrangement of...