Demonstrates the impact of 2-hydroxyimines on catalytic efficiency and selectivity in asymmetric organocatalysis.
aggregates are formed, the Mannich-type reaction proceeds inefficiently. A nonlinear effect analysis provided evidence of asymmetric amplification in the present Mannich-type reaction, proving the participation of aggregated species in the reaction pathway. Together, these results highlight the importance of controlling catalyst aggregation as a strategy to optimize the reactivity and selectivity in asymmetric organocatalysis.
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Hecht et al. (2026) studied this question.
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