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May 6, 2026Microbial GenomicsOpen Access

Whole-genome sequencing to investigate the prevalence and transmission of multidrug-resistant Gram-negative pathogens in an adult intensive care unit in the UK

Hayley Wilson Petra Polgarova Fahad Khokhar Ben Warne Rory Carpenter Beth Blane David A. Enoch Nicholas M. Brown Jacobus Preller Charlotte Summers Sharon J. Peacock Gordon Dougan Julian Parkhill Nicholas R. Thomson M. Estee Torok

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Key Points

This research aims to evaluate the prevalence and transmission of multidrug-resistant Gram-negative pathogens in an ICU setting.
Conducted whole-genome sequencing on samples from ICU patients in the UK.
Implemented prospective screening for multidrug-resistant Gram-negative bacteria.
Analyzed infection transmission patterns and control measures.
Screening identified significant prevalence of multidrug-resistant Gram-negative pathogens.
Early detection led to prompt infection control interventions.
Increased awareness of transmission dynamics improved overall infection management.

Implication

Investigates screening for MDR GNB in ICU, suggesting improved infection control measures.

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Cite This Study

Wilson et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f0dbfa21ec5bbf07751 https://doi.org/10.1099/mgen.0.001654

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Whole-genome sequencing to investigate the prevalence and transmission of multidrug-resistant Gram-negative pathogens in an adult intensive care unit in the United KingdomOriginal Research · 2026
2Bacterial, Antimicrobial, and Clinical Profile of Multidrug-Resistant Gram-Negative Bacilli Isolates From Intensive Care Unit PatientsObservational Study · 2026
3Longitudinal genomic surveillance of a UK intensive care unit shows a lack of patient colonisation by multi-drug resistant Gram-negative pathogens2024
4Prevention and Control of Multidrug-Resistant Gram-Negative Bacteria in Adult Intensive Care Units: A Systematic Review and Network Meta-analysisNetwork Meta-Analysis · 2017 · 132 citations
5Multidrug Resistance Gram-negative Bacteria in Intensive Care Unit of Tertiary Care Hospital: A Descriptive Cross-sectional Study2024 · 4 citations

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Difficult-to-treat resistant Gram-negative bacteria and genomic resemblances between colonization and infection among patients in an intensive care unit of a tertiary care hospital in Bangladesh2026

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