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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a2425 Timing as a Key Determinant of Intravenous Thrombolysis Bridging Therapy Before Endovascular Thrombectomy – A Multicenter Cohort Study From the Evatrisp Collaboration

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Authors

JMJeremy MoladTel Aviv Sourasky Medical CenterMAMarcel ArnoldUniversity Hospital of BernPMPatrik MichelUniversity Hospital of Lausanne

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Implication

Multicenter cohort study assesses timing of intravenous thrombolysis and outcomes in patients undergoing endovascular thrombectomy, highlighting significant time-dependent benefits.

Key Points

  • This research aims to evaluate how the timing of intravenous thrombolysis affects outcomes for patients undergoing endovascular thrombectomy.
  • Multicenter observational study assessing patients treated within 4 hours of symptom onset.
  • Compared outcomes for intravenous thrombolysis followed by endovascular thrombectomy versus direct endovascular thrombectomy across time intervals.
  • Included a subgroup analysis for octogenarian patients.
  • Bridging-IVT associated with improvement in favorable functional outcomes (48.3% vs 36.2%, p<0.001).
  • Lower mortality rates in IVT-EVT group (16.6% vs 25.3%, p<0.001) and increased successful recanalization (78% vs 76%, p=0.02).
  • Benefits of IVT-EVT significant mainly within the first 3 hours after symptom onset.

Cite This Study

Molad et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f3abfa21ec5bbf07a56https://doi.org/10.1093/esj/aakag023.1106
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes of Bridging Intravenous Thrombolysis Versus Endovascular Therapy Alone in Late-Window Acute Ischemic Stroke2024 · 16 citations
  2. 2ABSTRACT NUMBER: ESOC2026A1730 TIME-DEPENDENT EFFICACY OF THROMBOLYSIS BEFORE THROMBECTOMY: RESULTS FROM INTERNATIONAL REGISTRY OF STROKE CARE QUALITY (RES-Q)2026
  3. 3Abstract 364: Bridging With Intravenous Thrombolysis Before Endovascular Therapy Versus Endovascular Therapy Alone In Patients Aged 80 And Older2025
  4. 4ABSTRACT NUMBER: ESOC2026A1252 INTRAVENOUS THROMBOLYSIS IN ACUTE ISCHEMIC STROKE PATIENTS ON DIRECT ORAL ANTICOAGULANTS UNDERGOING ENDOVASCULAR THROMBECTOMY2026
  5. 5ABSTRACT NUMBER: ESOC2026A1682 SAFETY AND EFFICACY OF BRIDGING THERAPY VERSUS INTRAVENOUS THROMBOLYSIS ALONE OR DIRECT ENDOVASCULAR THROMBECTOMY BEYOND 4.5 HOURS: A POST-HOC ANALYSIS OF THE CHABLIS-T TRIALS2026