Abstract Background and aims The simplified CT-based Edinburgh-criteria for differential diagnosis of spontaneous lobar intracerebral hemorrhage (ICH) have been shown to identify ICH related to cerebral amyloid angiopathy (CAA). Data on ICH related to oral anticoagulation (OAC-ICH) in this context is limited. Methods Based on the NOACISP-Acute prospective single-centre registry of patients with OAC-ICH we analysed the presence and frequency of the Edinburgh CT-criteria in patients with acute lobar OAC-ICH and potentially related demographic and clinical measures. Statistical analyses were performed using Using chi-square or Fisher’s exact test, where appropriate. Results Out of 124 consecutive patients with OAC-ICH (aged 82, 42% female), 112 subjects had supratentorial ICH, with 45 lobar ICH (33 pure, 12 mixed). Hypertension was more common in patients with deep compared to lobar ICH (95% vs. 73 %, p=0.001). Of the lobar ICH, 24 subjects exhibited FLP and 35 SAH, respectively. Of these, 20 exhibited both FLP and SAH, fulfilling the simplified Edinburgh criteria for CAA. Compared to the large cohort of spontaneous ICH based on the TICH-2 cohort, our subjects with OAC-ICH were older, more frequently had lobar ICH (36 % vs 29 %; OR 1.41 0.94 – 2.08 and positive Edinburgh-criteria (44 % vs 31 % OR 1.82 0.93 – 3.49, albeit missing statistical significance. Conclusions As in sporadic ICH, the CT-Edinburgh-criteria for CAA can be observed in lobar OAC-ICH, potentially occurring more frequently. Future studies are warranted to determine whether the findings reflect CAA also in OAC-ICH and identify potential prognostic and therapeutic implications. Conflict of interest All authors: nothing to disclose.
Ruszkowski et al. (Fri,) studied this question.