Furin‐Mediated Intracellular Aggregation of Radioactive Molecules for Enhanced Radionuclide Imaging and Tumor Therapy

Key Points

• The aim is to explore the potential of furin-mediated aggregation of radioactive molecules for improving tumor imaging and therapy.
• Utilized I-labeled probes for SPECT imaging.
• Assessed effectiveness in HCT116 colon tumors exhibiting furin positivity.
• Evaluated therapeutic effects based on tumor growth suppression.
• Significant suppression of tumor growth was observed in furin-positive HCT116 colon tumors.
• Furin-mediated aggregation strategy notably enhanced retention of radioactive probes.
• Promising platform for effective imaging and treatment of various malignancies.