Key result
Low-dose atypical antipsychotics fully remit recurrent brief psychotic episodes in a facioscapulohumeral muscular dystrophy case.
Why the study?
Psychiatric comorbidities are rarely described in facioscapulohumeral muscular dystrophy, and reports linking psychosis with the condition are scarce.
Case Report (n=1)
No
This case highlights a rare association between Facioscapulohumeral muscular dystrophy and psychosis, suggesting potential central nervous system involvement.
May support low-dose atypicals for psychosis in FSHD; leaves open CNS involvement pending dedicated research.
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscular dystrophy characterized by progressive weakness of facial and scapulohumeral muscles. Psychiatric comorbidities are rarely described. We present a 39-year-old male diagnosed with FSHD who experienced recurrent brief psychotic episodes that fully remitted with low-dose atypical antipsychotics. The case highlights potential central nervous system involvement in FSHD and underscores the need for psychiatric evaluation in affected families. While literature exists linking psychosis and other muscular dystrophies, this is among the few reports worldwide linking psychosis with FSHD.
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Braganza et al. (2026) conducted a case report in Facioscapulohumeral muscular dystrophy (FSHD) and psychosis (n=1). atypical antipsychotics was evaluated on remission of psychotic episodes. Low-dose atypical antipsychotics fully remitted recurrent brief psychotic episodes in a 39-year-old male with facioscapulohumeral muscular dystrophy.
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