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May 8, 2026Poultry ScienceOpen Access

Hepatoprotective Efficacy of Silymarin-loaded Metal-Organic Frameworks Against CCl4 Toxicity in Broilers: A Dose-dependent Study

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Authors

NANouf AldawoodMAManahil ArshadRHRiaz Hussain

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Overview

Randomized trial examines hepatoprotection in broilers using silymarin-loaded frameworks, suggesting enhanced outcomes.

Key Points

  • This research aims to evaluate the hepatoprotective effects of silymarin-loaded metal-organic frameworks against carbon tetrachloride (CCl4) induced liver damage in broilers.
  • 105 broilers were randomly assigned to 7 groups, including treatment and control groups.
  • Carbon tetrachloride was used to induce hepatotoxicity, with treatments of silymarin@ZIF-8 at varying dosages (5, 10, 15 mg/kg).
  • Liver function and oxidative stress were assessed through biochemical tests, histopathological analysis, and comet assays over 20 days.
  • CCl4 exposure significantly altered hematological parameters and liver function, indicating severe hepatotoxicity.
  • Treatment with silymarin@ZIF-8 (especially at 15 mg/kg) showed marked improvements in liver enzyme levels and oxidative DNA damage.
  • The formulation demonstrated better therapeutic efficacy compared to conventional silymarin, due to higher bioavailability and targeted delivery.

Cite This Study

Aldawood et al. (2026) studied this question.

synapsesocial.com/papers/69fd7fb8bfa21ec5bbf08520https://doi.org/10.1016/j.psj.2026.107082
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insights into the Therapeutic Potential of Silymarin-encapsulated CME@ZIF-8 Against CCl4-induced Toxicity in Broiler Chicks2026
  2. 2Evaluation of commercial doses of a feed additive and silymarin on broiler performance with and without CCl4-induced liver damage2024 · 6 citations
  3. 3BIOCHEMICAL AND HISTOLOGICAL STUDY OF THREE DIFFERENT MULTIHERBAL COMPOSITIONS ON HEPATOXICITY INDUCED BY CARBON TETRA CHLORIDE (CCL4) IN ALBINO RATS2024 · 1 citations
  4. 4INVESTIGATING THE POTENTIAL OF SILYMARIN AND/OR SPIRULINA PLATENSIS TO ATTENUATE THE DELETERIOUS CONSEQUENCES OF AFLATOXIN CONTAMINATION IN BROILERS’ FEEDS2024 · 1 citations
  5. 5Evaluating the therapeutic effect of different forms of silymarin on liver status and expression of some genes involved in fat metabolism, antioxidants and anti‐inflammatory in older laying hens2024 · 1 citations