February 26, 2021Open Access

High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy

Structured PICO

Population

Cardiomyocytes in the context of diabetic cardiomyopathy (DCM) and high glucose-induced hypertrophy

Intervention

High glucose exposure / investigation of Orai1-Drp1 axis

Outcome

Drp1-mediated mitochondrial fission and cardiomyocyte hypertrophysurrogate

The Orai1-Drp1 axis mediates high glucose-induced mitochondrial fission and cardiomyocyte hypertrophy, presenting a potential therapeutic target for diabetic cardiomyopathy.

Abstract

entry, via activation by p-ERK1/2-mediated phosphorylation at S616 or CnA-mediated dephosphorylation at S637 in DCM. Thus, the Orai1-Drp1 axis is a novel target for treating DCM.

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Cite This Study

Wu et al. (Fri,) studied this question.

synapsesocial.com/papers/69fdb70c7f24f003e82718f5 https://doi.org/https://doi.org/10.1038/s41419-021-03502-4

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