Population
Human coronary resistance vessels dissected from atrial appendages obtained during cardiac surgery
Comparison
Stepped increases in intraluminal pressure, and… vs Passive diameter/baseline conditions; vessels…
Design
Preclinical
Authors
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May contribute to hypertensive coronary microvascular dysfunction; first human demonstration leaves open mechanistic and therapeutic implications.
This study provides the first demonstration of myogenic constriction in the human coronary microcirculation, highlighting the roles of VDCC and PKC, and showing enhanced constriction in hypertension.
Miller et al. (1997) studied this question.