Why the study?
Controversies exist regarding the roles of coronary endothelia in dexmedetomidine-induced cardioprotection against myocardial ischemia/reperfusion injury.
Does dexmedetomidine preconditioning attenuate ischemia/reperfusion injury in isolated rat hearts with endothelial dysfunction?
Does dexmedetomidine preconditioning attenuate ischemia/reperfusion injury in isolated rat hearts with endothelial dysfunction?
Dexmedetomidine preconditioning provides cardioprotection against ischemia/reperfusion injury independent of endothelial function in an isolated rat heart model.
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Hypothesis-generating for endothelial-independent dexmedetomidine cardioprotection; leaves open human translation.
He et al. (2019) studied this question.
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