Why the study?
Does placement of an ameroid occluder on the left circumflex coronary artery induce coronary collateral development in swine?
Population
Swine model of coronary artery occlusion
Comparison
Placement of an ameroid occluder on the left… vs Animal not subjected to coronary artery occlusion
Design
Preclinical
Follow-up
2 to 16 weeks
Authors
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Swine model data on transient collateral growth should not change clinical practice; leaves open optimal intervention windows for human angiogenesis trials.
Does placement of an ameroid occluder on the left circumflex coronary artery induce coronary collateral development in swine?
In a swine model, coronary artery occlusion stimulates rapid but self-limiting collateral vessel proliferation and DNA synthesis within the first 2-3 weeks.
White et al. (1992) studied this question.
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