Magnesium in acute myocardial infarction
Why the study?
Does intravenous magnesium reduce mortality and morbidity in patients with acute myocardial infarction?
Population
Patients with acute myocardial infarction
Design
Editorial
Authors
Discussion
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Member takes
Implication
Despite early promising data from small trials and experimental models, routine use of intravenous magnesium in acute myocardial infarction is not supported by the ISIS 4 trial.
Structured PICO
Does intravenous magnesium reduce mortality and morbidity in patients with acute myocardial infarction?
P
Population
Patients with acute myocardial infarction
I
Intervention
Intravenous magnesium
O
Outcome
Mortality and morbidityhard clinical
Despite early promising data from small trials and experimental models, routine use of intravenous magnesium in acute myocardial infarction is not supported by the ISIS 4 trial.
Limitations
- Experimental studies often lack rigorous design
- Few experimental studies are randomised or blinded
- Publication bias is likely in early studies
Cite This Study
Yusuf et al. (1995) studied this question.