June 1, 1989AJP Renal Physiology
Endothelin: a potent renal and systemic vasoconstrictor peptide
Population
Anesthetized Munich-Wistar rats
Design
Preclinical
Follow-up
greater than 90 min
Authors
Discussion
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Member takes
Implication
Endothelin causes sustained vasoconstriction in this model; leaves open its role in human microvasculopathies.
Structured PICO
P
Population
Anesthetized Munich-Wistar rats
I
Intervention
Intravenous endothelin (bolus injections of 5-450 pmol or continuous infusions of 0.63 pmol/min)
O
Outcome
Systemic and renal pressor effects, including changes in renal plasma flow, glomerular filtration rate, and arteriolar resistancesurrogate
Endothelin is a potent systemic and renal vasoconstrictor that significantly alters renal hemodynamics, suggesting a role in clinical microvasculopathies.
Cite This Study
King et al. (1989) studied this question.