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April 1, 1989Proceedings of the National Academy of SciencesOpen Access

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

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Population

Human genomic DNA library, porcine and rat genomes, isolated porcine coronary artery strips, and…

Design

Preclinical

Authors

AIAkiko InoueOsaka University of Pharmaceutical Sciences
Masashi Yanagisawa
Masashi YanagisawaVascular MedicineSKSadao KimuraVascular / Pulmonary Vascular

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Implication

Hypothesis-generating for endothelin receptor subtypes; leaves open clinical translation in human disease.

Structured PICO

P
Population
Human genomic DNA library, porcine and rat genomes, isolated porcine coronary artery strips, and anesthetized rats
I
Intervention
Synthetic endothelin isopeptides (ET-1, ET-2, and ET-3)
O
Outcome
Vasoconstrictor and pressor responsessurrogate

The identification of three distinct human endothelin isopeptides with differing pharmacological profiles suggests the existence of multiple endothelin receptor subtypes.

Cite This Study

Inoue et al. (1989) studied this question.

synapsesocial.com/papers/69fe797ed8476229fea358dchttps://doi.org/10.1073/pnas.86.8.2863
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synthesis and disulfide structure determination of porcine endothelin: an endothelium‐derived vasoconstricting peptide1988 · 92 citations
  2. 2Structure and gene organization of bovine neuromedin K precursor.1986 · 231 citations