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August 1, 1991New England Journal of MedicineOpen Access

A Double-Blind Trial of a 16-Hour Transdermal Nicotine Patch in Smoking Cessation

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Authors

PTPhilip TønnesenJNJesper NørregaardKSKåre Simonsen

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Overview

Randomized double-blind trial reveals higher sustained abstinence rates with a transdermal nicotine patch in adult smokers, indicating its efficacy as a safe cessation aid.

Key Points

  • To evaluate the efficacy and safety of a 16-hour transdermal nicotine patch compared with a placebo patch for smoking cessation.
  • Conducted a double-blind randomized trial enrolling 289 smokers (207 women, 82 men) treated for 16 weeks.
  • Assigned 145 participants to a 16-hour nicotine patch (15 ± 3.5 mg nicotine) and 144 participants to a placebo patch, with follow-up through 52 weeks.
  • Sustained abstinence rates were significantly higher with the nicotine patch versus placebo at 6 weeks (53% vs 17%), 12 weeks (41% vs 10%), 26 weeks (24% vs 5%), and 52 weeks (17% vs 4%) (P < 0.0001).
  • Adverse effects leading to study withdrawal occurred in only 2 participants in the nicotine group and 1 participant in the placebo group.

Cite This Study

Tønnesen et al. (1991) studied this question.

synapsesocial.com/papers/69fe79c9d8476229fea35a1chttps://doi.org/10.1056/nejm199108013250503
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Also Consider

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