Why the study?
Does coarctation of the ascending aorta compared to the suprarenal abdominal aorta differentially affect the development of pressure-overload left ventricular hypertrophy in rats?
Population
25 6-weeks-old Wistar rats
Comparison
Coarctation of the ascending aorta over 4 weeks vs Coarctation of the suprarenal abdominal aorta…
Design
Preclinical
Follow-up
4 weeks
Authors
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Less concentric LVH with early vs late systolic loading in rats; leaves open translation to human pressure-overload states.
Does coarctation of the ascending aorta compared to the suprarenal abdominal aorta differentially affect the development of pressure-overload left ventricular hypertrophy in rats?
Sustained early systolic loading from ascending aorta coarctation leads to less concentric left ventricular hypertrophy compared to late systolic loading from abdominal aorta coarctation in rats.
Kobayashi et al. (1996) studied this question.
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