Why the study?
Does pretreatment with cardioselective (atenolol) or non-selective (timolol) beta-blockers alter the hypokalemic and cardiovascular responses to adrenaline infusion in normal volunteers?
Population
9 normal volunteers
Comparison
Atenolol or timolol for 5 days prior to… vs Placebo for 5 days prior to intravenous…
Design
Other
Authors
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Non-selective beta-blockade may better mitigate adrenaline-driven hypokalemia than cardioselective agents; confirms beta-2 mediation and informs selection in catecholamine excess.
Does pretreatment with cardioselective (atenolol) or non-selective (timolol) beta-blockers alter the hypokalemic and cardiovascular responses to adrenaline infusion in normal volunteers?
Non-selective beta-blockade with timolol prevents adrenaline-induced hypokalemia more effectively than cardioselective blockade with atenolol, suggesting the mechanism is beta-2 adrenoceptor mediated.
Struthers et al. (1983) studied this question.
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